Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19

SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demo...

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Autores principales: Valyaeva, Anna A., Zharikova, Anastasia A., Kasianov, Artem S., Vassetzky, Yegor S., Sheval, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576138/
https://www.ncbi.nlm.nih.gov/pubmed/33082395
http://dx.doi.org/10.1038/s41598-020-74598-5
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author Valyaeva, Anna A.
Zharikova, Anastasia A.
Kasianov, Artem S.
Vassetzky, Yegor S.
Sheval, Eugene V.
author_facet Valyaeva, Anna A.
Zharikova, Anastasia A.
Kasianov, Artem S.
Vassetzky, Yegor S.
Sheval, Eugene V.
author_sort Valyaeva, Anna A.
collection PubMed
description SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.
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spelling pubmed-75761382020-10-21 Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19 Valyaeva, Anna A. Zharikova, Anastasia A. Kasianov, Artem S. Vassetzky, Yegor S. Sheval, Eugene V. Sci Rep Article SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences. Nature Publishing Group UK 2020-10-20 /pmc/articles/PMC7576138/ /pubmed/33082395 http://dx.doi.org/10.1038/s41598-020-74598-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Valyaeva, Anna A.
Zharikova, Anastasia A.
Kasianov, Artem S.
Vassetzky, Yegor S.
Sheval, Eugene V.
Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
title Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
title_full Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
title_fullStr Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
title_full_unstemmed Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
title_short Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19
title_sort expression of sars-cov-2 entry factors in lung epithelial stem cells and its potential implications for covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576138/
https://www.ncbi.nlm.nih.gov/pubmed/33082395
http://dx.doi.org/10.1038/s41598-020-74598-5
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