Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy

As recent advancements in the chimeric antigen receptor-T cells have revolutionized the way blood cancers are handled, potential benefits from producing off-the-shelf, standardized immune cells entail the need for development of allogeneic immune cell therapy. However, host rejection driven by HLA d...

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Detalles Bibliográficos
Autores principales: Lee, Jeewon, Sheen, Joong Hyuk, Lim, Okjae, Lee, Yunjung, Ryu, Jihye, Shin, Duckhyang, Kim, Yu Young, Kim, Munkyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576162/
https://www.ncbi.nlm.nih.gov/pubmed/33082438
http://dx.doi.org/10.1038/s41598-020-74772-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576162/
https://www.ncbi.nlm.nih.gov/pubmed/33082438
http://dx.doi.org/10.1038/s41598-020-74772-9

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