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Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy
As recent advancements in the chimeric antigen receptor-T cells have revolutionized the way blood cancers are handled, potential benefits from producing off-the-shelf, standardized immune cells entail the need for development of allogeneic immune cell therapy. However, host rejection driven by HLA d...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576162/ https://www.ncbi.nlm.nih.gov/pubmed/33082438 http://dx.doi.org/10.1038/s41598-020-74772-9 |