GSK3‐ARC/Arg3.1 and GSK3‐Wnt signaling axes trigger amyloid‐β accumulation and neuroinflammation in middle‐aged Shugoshin 1 mice

The cerebral amyloid‐β accumulation that begins in middle age is considered the critical triggering event in the pathogenesis of late‐onset Alzheimer's disease (LOAD). However, the molecular mechanism remains elusive. The Shugoshin 1 (Sgo1(−/+)) mouse model, a model for mitotic cohesinopathy‐ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Chinthalapally V., Farooqui, Mudassir, Madhavaram, Avanish, Zhang, Yuting, Asch, Adam S., Yamada, Hiroshi Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576275/
https://www.ncbi.nlm.nih.gov/pubmed/32857910
http://dx.doi.org/10.1111/acel.13221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576275/
https://www.ncbi.nlm.nih.gov/pubmed/32857910
http://dx.doi.org/10.1111/acel.13221

Ejemplares similares