Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy

Loss-of-function mutations in both alleles of the human insulin receptor gene (INSR) cause extreme insulin resistance (IR) and usually death in childhood, with few effective therapeutic options. Bivalent antireceptor antibodies can elicit insulin-like signaling by mutant INSR in cultured cells, but...

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Detalles Bibliográficos
Autores principales: Brierley, Gemma V., Webber, Hannah, Rasijeff, Eerika, Grocott, Sarah, Siddle, Kenneth, Semple, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576564/
https://www.ncbi.nlm.nih.gov/pubmed/32816962
http://dx.doi.org/10.2337/db20-0345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576564/
https://www.ncbi.nlm.nih.gov/pubmed/32816962
http://dx.doi.org/10.2337/db20-0345

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