A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages, and Lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity

Elevated expression of E2F1 in adipocyte fraction of human visceral adipose tissue (hVAT) associates with a poor cardiometabolic profile. We hypothesized that beyond directly activating autophagy and MAP3K5 (ASK)–MAP kinase signaling, E2F1 governs a distinct transcriptome that contributes to adipose...

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Detalles Bibliográficos
Autores principales: Maixner, Nitzan, Pecht, Tal, Haim, Yulia, Chalifa-Caspi, Vered, Goldstein, Nir, Tarnovscki, Tania, Liberty, Idit F., Kirshtein, Boris, Golan, Rachel, Berner, Omer, Monsonego, Alon, Bashan, Nava, Blüher, Matthias, Rudich, Assaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576574/
https://www.ncbi.nlm.nih.gov/pubmed/32732304
http://dx.doi.org/10.2337/db19-1231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576574/
https://www.ncbi.nlm.nih.gov/pubmed/32732304
http://dx.doi.org/10.2337/db19-1231

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