Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless proliferation. Here, we uncover two distinct mechanisms by which naturally occurring oxidized dNTPs and therapeutic dNTPs inhibit telomerase-medi...

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Detalles Bibliográficos
Autores principales: Sanford, Samantha L., Welfer, Griffin A., Freudenthal, Bret D., Opresko, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576608/
https://www.ncbi.nlm.nih.gov/pubmed/33082336
http://dx.doi.org/10.1038/s41467-020-19115-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576608/
https://www.ncbi.nlm.nih.gov/pubmed/33082336
http://dx.doi.org/10.1038/s41467-020-19115-y

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