Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness

BACKGROUND: How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed this issue through the first structurome-scale computational investigation, in whi...

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Detalles Bibliográficos
Autores principales: Schwersensky, Martin, Rooman, Marianne, Pucci, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576759/
https://www.ncbi.nlm.nih.gov/pubmed/33081759
http://dx.doi.org/10.1186/s12915-020-00870-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576759/
https://www.ncbi.nlm.nih.gov/pubmed/33081759
http://dx.doi.org/10.1186/s12915-020-00870-9

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