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Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness
BACKGROUND: How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed this issue through the first structurome-scale computational investigation, in whi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576759/ https://www.ncbi.nlm.nih.gov/pubmed/33081759 http://dx.doi.org/10.1186/s12915-020-00870-9 |