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Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling

Photoreceptors, the primary site of phototransduction in the retina, require energy and metabolites to constantly renew their outer segments. They preferentially consume most glucose through aerobic glycolysis despite possessing abundant mitochondria and enzymes for oxidative phosphorylation (OXPHOS...

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Detalles Bibliográficos
Autores principales: Zhang, Rui, Shen, Weiyong, Du, Jianhai, Gillies, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576789/
https://www.ncbi.nlm.nih.gov/pubmed/33082308
http://dx.doi.org/10.1038/s41419-020-03103-7