CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats

Immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome is a rare autosomal recessive disorder that is caused by mutations in either DNMT3B, ZBTB24, CDCA7, HELLS, or yet unidentified gene(s). Previously, we reported that the CDCA7/HELLS chromatin remodeling complex facilitates non...

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Detalles Bibliográficos
Autores principales: Unoki, Motoko, Sharif, Jafar, Saito, Yuichiro, Velasco, Guillaume, Francastel, Claire, Koseki, Haruhiko, Sasaki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576824/
https://www.ncbi.nlm.nih.gov/pubmed/33082427
http://dx.doi.org/10.1038/s41598-020-74636-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576824/
https://www.ncbi.nlm.nih.gov/pubmed/33082427
http://dx.doi.org/10.1038/s41598-020-74636-2

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