Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations

In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity determining regions (CDRs) shaping the antigen-bindin...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Pomarici, Nancy D., Math, Barbara A., Kroell, Katharina B., Waibl, Franz, Bujotzek, Alexander, Georges, Guy, Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576833/
https://www.ncbi.nlm.nih.gov/pubmed/33082531
http://dx.doi.org/10.1038/s42003-020-01319-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576833/
https://www.ncbi.nlm.nih.gov/pubmed/33082531
http://dx.doi.org/10.1038/s42003-020-01319-z

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