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Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations
In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity determining regions (CDRs) shaping the antigen-bindin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576833/ https://www.ncbi.nlm.nih.gov/pubmed/33082531 http://dx.doi.org/10.1038/s42003-020-01319-z |