RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice

BACKGROUND: Targeting RNA polymerase-1 (POL1) machinery is a new strategy for suppression of multiple sclerosis (MS) relapse activity. Oral administration of POL1 inhibitor RAM-589.555, which is characterized by high permeability and bioavailability in naïve mice, ameliorates proteolipid protein (PL...

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Detalles Bibliográficos
Autores principales: Zilkha-Falb, Rina, Rachutin-Zalogin, Tatyana, Cleaver, Lakota, Gurevich, Michael, Achiron, Anat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576835/
https://www.ncbi.nlm.nih.gov/pubmed/33081798
http://dx.doi.org/10.1186/s12974-020-01983-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576835/
https://www.ncbi.nlm.nih.gov/pubmed/33081798
http://dx.doi.org/10.1186/s12974-020-01983-2

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