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Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption

Chronic kidney disease (CKD) has significant effects on renal clearance (CL(r)) of drugs. Physiologically‐based pharmacokinetic (PBPK) models have been used to predict CKD effects on transporter‐mediated renal active secretion and CL(r) for hydrophilic nonpermeable compounds. However, no studies hav...

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Detalles Bibliográficos
Autores principales: Huang, Weize, Isoherranen, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577018/
https://www.ncbi.nlm.nih.gov/pubmed/32977369
http://dx.doi.org/10.1002/psp4.12553