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Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption
Chronic kidney disease (CKD) has significant effects on renal clearance (CL(r)) of drugs. Physiologically‐based pharmacokinetic (PBPK) models have been used to predict CKD effects on transporter‐mediated renal active secretion and CL(r) for hydrophilic nonpermeable compounds. However, no studies hav...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577018/ https://www.ncbi.nlm.nih.gov/pubmed/32977369 http://dx.doi.org/10.1002/psp4.12553 |