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Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse
We generated an NOD/Shi-scid-IL2Rγ(null) (NOG) mouse deficient for the Fcer1g and Fcgr2b genes (NOG-FcγR(−/−) mice), in which monocytes/macrophages do not express activating (FcγRI, III, and IV) or inhibitory (FcγRIIB) Fcγ receptors. Antibody-dependent cellular cytotoxicity (ADCC) by innate immune c...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577188/ https://www.ncbi.nlm.nih.gov/pubmed/33117338 http://dx.doi.org/10.3389/fimmu.2020.532684 |