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Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse

We generated an NOD/Shi-scid-IL2Rγ(null) (NOG) mouse deficient for the Fcer1g and Fcgr2b genes (NOG-FcγR(−/−) mice), in which monocytes/macrophages do not express activating (FcγRI, III, and IV) or inhibitory (FcγRIIB) Fcγ receptors. Antibody-dependent cellular cytotoxicity (ADCC) by innate immune c...

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Detalles Bibliográficos
Autores principales:	Katano, Ikumi, Ito, Ryoji, Kawai, Kenji, Takahashi, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577188/ https://www.ncbi.nlm.nih.gov/pubmed/33117338 http://dx.doi.org/10.3389/fimmu.2020.532684

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