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A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays

The current methods of generating human cerebral organoids rely excessively on the use of Matrigel or other external extracellular matrices (ECM) for cell micro-environmental modulation. Matrigel embedding is problematic for long-term culture and clinical applications due to high inconsistency and o...

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Detalles Bibliográficos
Autores principales: Chen, Cheng, Rengarajan, Venkatakrishnan, Kjar, Andrew, Huang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577195/
https://www.ncbi.nlm.nih.gov/pubmed/33134606
http://dx.doi.org/10.1016/j.bioactmat.2020.10.003