Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from cata...

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Detalles Bibliográficos
Autores principales: Low, Benjamin E., Christianson, Gregory J., Lowell, Emily, Qin, Wenning, Wiles, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577234/
https://www.ncbi.nlm.nih.gov/pubmed/33025844
http://dx.doi.org/10.1080/19420862.2020.1829334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577234/
https://www.ncbi.nlm.nih.gov/pubmed/33025844
http://dx.doi.org/10.1080/19420862.2020.1829334

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