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Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice
A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from cata...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577234/ https://www.ncbi.nlm.nih.gov/pubmed/33025844 http://dx.doi.org/10.1080/19420862.2020.1829334 |