Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody biophysical properties, a clear gap still exists betwee...

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Detalles Bibliográficos
Autores principales: Chen, Zhiqiang, Qian, Yueming, Song, Yuanli, Xu, Xuankuo, Tao, Li, Mussa, Nesredin, Ghose, Sanchayita, Li, Zheng Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577236/
https://www.ncbi.nlm.nih.gov/pubmed/33044887
http://dx.doi.org/10.1080/19420862.2020.1829338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577236/
https://www.ncbi.nlm.nih.gov/pubmed/33044887
http://dx.doi.org/10.1080/19420862.2020.1829338

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