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Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics
Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody biophysical properties, a clear gap still exists betwee...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577236/ https://www.ncbi.nlm.nih.gov/pubmed/33044887 http://dx.doi.org/10.1080/19420862.2020.1829338 |