Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans

Two-pore physiologically-based pharmacokinetics (PBPK) for biologics describes the tissue distribution and elimination kinetics of soluble proteins as a function of their hydrodynamic radius and the physiological properties of the organs. Whilst many studies have been performed in rodents to paramet...

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Detalles Bibliográficos
Autores principales: Sepp, Armin, Bergström, Mats, Davies, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577242/
https://www.ncbi.nlm.nih.gov/pubmed/33073698
http://dx.doi.org/10.1080/19420862.2020.1832861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577242/
https://www.ncbi.nlm.nih.gov/pubmed/33073698
http://dx.doi.org/10.1080/19420862.2020.1832861

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