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Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans

Two-pore physiologically-based pharmacokinetics (PBPK) for biologics describes the tissue distribution and elimination kinetics of soluble proteins as a function of their hydrodynamic radius and the physiological properties of the organs. Whilst many studies have been performed in rodents to paramet...

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Detalles Bibliográficos
Autores principales:	Sepp, Armin, Bergström, Mats, Davies, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577242/ https://www.ncbi.nlm.nih.gov/pubmed/33073698 http://dx.doi.org/10.1080/19420862.2020.1832861

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