Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages

We have positionally cloned the Ym1 gene, with a duplication and a promoter polymorphism, as a major regulator of inflammation. Mice with the RIIIS/J haplotype, with the absence of Ym1 expression, showed reduced susceptibility to mannan-enhanced collagen antibody–induced arthritis and to chronic art...

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Detalles Bibliográficos
Autores principales: Zhu, Wenhua, Lönnblom, Erik, Förster, Michael, Johannesson, Martina, Tao, Pei, Meng, Liesu, Lu, Shemin, Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577715/
https://www.ncbi.nlm.nih.gov/pubmed/33087360
http://dx.doi.org/10.1126/sciadv.aba9337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577715/
https://www.ncbi.nlm.nih.gov/pubmed/33087360
http://dx.doi.org/10.1126/sciadv.aba9337

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