Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to meet product specifications. Although many mitigati...

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Detalles Bibliográficos
Autores principales: Tang, Peifeng, Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Hoffman, Laurel, Du, Cheng, Song, Yuanli, Tao, Li, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577745/
https://www.ncbi.nlm.nih.gov/pubmed/33031716
http://dx.doi.org/10.1080/19420862.2020.1829336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577745/
https://www.ncbi.nlm.nih.gov/pubmed/33031716
http://dx.doi.org/10.1080/19420862.2020.1829336

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