Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents

Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC(50) values in the range of 0.4–50 μM in several cancer cell lines including murine metastatic br...

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Detalles Bibliográficos
Autores principales: Solano, Lucas N., Nelson, Grady L., Ronayne, Conor T., Jonnalagadda, Shirisha, Jonnalagadda, Sravan K., Kottke, Kaija, Chitren, Robert, Johnson, Joseph L., Pandey, Manoj K., Jonnalagadda, Subash C., Mereddy, Venkatram R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578069/
https://www.ncbi.nlm.nih.gov/pubmed/33087745
http://dx.doi.org/10.1038/s41598-020-74572-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578069/
https://www.ncbi.nlm.nih.gov/pubmed/33087745
http://dx.doi.org/10.1038/s41598-020-74572-1

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