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Short-term high-dose gavage of hydroxychloroquine changes gut microbiota but not the intestinal integrity and immunological responses in mice

AIMS: Hydroxychloroquine (HCQ), a widely used antimalarial drug, is proposed to treat coronavirus disease 2019 (COVID-19). However, no report is currently available regarding the direct effects of HCQ on gut microbiota, which is associated with the outcomes of elderly patients with COVID-19. Here, w...

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Detalles Bibliográficos
Autores principales: Pan, Zhi-Yuan, Chang, Yu-Xiao, Han, Ni, Hou, Feng-Yi, Lee, B.J. Yang, Zhi, Fa-Chao, Yang, Rui-Fu, Bi, Yu-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578705/
https://www.ncbi.nlm.nih.gov/pubmed/33131749
http://dx.doi.org/10.1016/j.lfs.2020.118450