Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy

The function of Keap1 (Kelch-like ECH-associated protein 1), a sensor of oxidative and electrophilic stress, in the radiosensitivity of cancer cells remains elusive. Here, we investigated the effects of pharmacological inhibition of Keap1 with ML344 on radiosensitivity, DNA double-strand break (DSB)...

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Detalles Bibliográficos
Autores principales: Deville, Sara Sofia, Luft, Susanne, Kaufmann, Maria, Cordes, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578798/
https://www.ncbi.nlm.nih.gov/pubmed/33087706
http://dx.doi.org/10.1038/s41419-020-03100-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578798/
https://www.ncbi.nlm.nih.gov/pubmed/33087706
http://dx.doi.org/10.1038/s41419-020-03100-w

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