EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Forkhead‐Box Class O 4 (FOXO4) is involved in critical biological functions, but its response to EGF‐PKB/Akt signal regulation is not well characterized. Here, it is reported that FOXO4 levels are downregulated in response to EGF treatment, with concurrent elevation of COP9 Signalosome subunit 6 (CS...

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Detalles Bibliográficos
Autores principales: Choi, Hyun Ho, Zou, Shaomin, Wu, Jian‐lin, Wang, Huashe, Phan, Liem, Li, Kai, Zhang, Peng, Chen, Daici, Liu, Qingxin, Qin, Baifu, Nguyen, Thu Anh Thai, Yeung, Sai‐Ching J., Fang, Lekun, Lee, Mong‐Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578864/
https://www.ncbi.nlm.nih.gov/pubmed/33101846
http://dx.doi.org/10.1002/advs.202000681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578864/
https://www.ncbi.nlm.nih.gov/pubmed/33101846
http://dx.doi.org/10.1002/advs.202000681

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