Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling

Pioglitazone (PIO) attenuates cisplatin nephrotoxicity whereas the underlying mechanism remains unknown. Apoptosis is associated with mitochondrial dysfunction and SIRT1 activation can decrease cell apoptosis in cisplatin nephrotoxicity. Therefore, we explored whether the protective effect of PIO in...

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Detalles Bibliográficos
Autores principales: Zhang, Jiong, Zou, Yang, Cheng‐Jing, Yan, Xiang‐Heng, Lu, Wang, Xue‐Peng, Yu, Xiao‐Jia, Li, Gui‐sen, Wang, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578900/
https://www.ncbi.nlm.nih.gov/pubmed/32881246
http://dx.doi.org/10.1111/jcmm.15782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578900/
https://www.ncbi.nlm.nih.gov/pubmed/32881246
http://dx.doi.org/10.1111/jcmm.15782

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