First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and -Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy 
Subjects

BACKGROUND: 2-iminobiotin (2-IB) is an investigational neuroprotective agent in development for the reduction of brain cell injury after cerebral hypoxia-ischemia. OBJECTIVE: The present first-in-human study evaluated the safety, tolerability, pharmacokinetics (PK) and -dynamics (PD) of 2-IB in heal...

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Detalles Bibliográficos
Autores principales: van Hoogdalem, Ewoud-Jan, Peeters-Scholte, Cacha M.P.C.D., Leufkens, Paul W.T.J., Hartstra, Jan, van Lier, Jan J., de Leede, Leo G.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579265/
https://www.ncbi.nlm.nih.gov/pubmed/31625480
http://dx.doi.org/10.2174/1574884714666191017111109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579265/
https://www.ncbi.nlm.nih.gov/pubmed/31625480
http://dx.doi.org/10.2174/1574884714666191017111109

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