Cargando…

The AKR1C3/AR‐V7 complex maintains CRPC tumour growth by repressing B4GALT1 expression

Multiple mechanisms contribute to the survival and growth of metastatic castration‐resistant prostate cancer (mCRPC) cells without androgen, including androgen receptor splice variants (AR‐V) and de novo intratumoral androgen synthesis. AKR1C3 is a critical androgenic enzyme that plays different rol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Bin, Wu, Shiqi, Fang, Yong, Sun, Guangxi, He, Dalin, Hsieh, Jer‐Tsong, Wang, Xinyang, Zeng, Hao, Wu, Kaijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579719/ https://www.ncbi.nlm.nih.gov/pubmed/32902124 http://dx.doi.org/10.1111/jcmm.15831

Ejemplares similares

RETRACTED ARTICLE: Targeting KDM4A-AS1 represses AR/AR-Vs deubiquitination and enhances enzalutamide response in CRPC
por: Zhang, Boya, et al.
Publicado: (2021)

Retraction Note: Targeting KDM4A-AS1 represses AR/AR-Vs deubiquitination and enhances enzalutamide response in CRPC
por: Zhang, Boya, et al.
Publicado: (2023)

The expression and function of RASAL2 in renal cell carcinoma angiogenesis
por: Hui, Ke, et al.
Publicado: (2018)

Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus
por: Zhang, Tingting, et al.
Publicado: (2015)

RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer
por: Hui, Ke, et al.
Publicado: (2017)

Saracatinib synergizes with enzalutamide to downregulate AR activity in CRPC
por: White, Ralph E., et al.
Publicado: (2023)

RASAL2 regulates the cell cycle and cyclin D1 expression through PI3K/AKT signalling in prostate tumorigenesis
por: Wang, Qi, et al.
Publicado: (2022)

The roles and mechanism of IFIT5 in bladder cancer epithelial–mesenchymal transition and progression
por: Huang, Jun, et al.
Publicado: (2019)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2018)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2021)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC
por: Wang, Hung-Jung, et al.
Publicado: (2018)

Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)
por: Chandrasekaran, Balaji, et al.
Publicado: (2023)

Undesirable Status of Prostate Cancer Cells after Intensive Inhibition of AR Signaling: Post-AR Era of CRPC Treatment
por: Makino, Tomoyuki, et al.
Publicado: (2021)

Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling
por: Zhang, Ningfang, et al.
Publicado: (2022)

C1GALT1 in health and disease
por: Sun, Xiaojie, et al.
Publicado: (2021)

Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling
por: Zhang, Xiong, et al.
Publicado: (2021)

B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells
por: De Vitis, Claudia, et al.
Publicado: (2019)

Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203
por: Wang, Liang, et al.
Publicado: (2018)

Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52
por: Joshi, Jugal Bharat, et al.
Publicado: (2017)

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
por: Rižner, Tea Lanišnik
Publicado: (2012)

Update on the role of C1GALT1 in cancer
por: Xia, Tong, et al.
Publicado: (2022)

Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers
por: Laffin, Brian, et al.
Publicado: (2012)

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
por: Zhu, Pengfei, et al.
Publicado: (2021)

AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas
por: Hojnik, Marko, et al.
Publicado: (2021)

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs
por: Zhou, Jiancheng, et al.
Publicado: (2017)

SAT-330 Preclinical Screen of Patient CRPC Tumors Shows Sensitivity to Bromodomain Inhibitors Includes AR-null and Neuroendocrine Disease
por: Risbridger, Gail, et al.
Publicado: (2019)

Expression and Impact of C1GalT1 in Cancer Development and Progression
por: Wan, Yangu, et al.
Publicado: (2021)

Two Hydroxyproline Galactosyltransferases, GALT5 and GALT2, Function in Arabinogalactan-Protein Glycosylation, Growth and Development in Arabidopsis
por: Basu, Debarati, et al.
Publicado: (2015)

Structural basis for the synthesis of the core 1 structure by C1GalT1
por: González-Ramírez, Andrés Manuel, et al.
Publicado: (2022)

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues
por: Chen, Wei, et al.
Publicado: (2016)

Inhibitory selectivity to the AKR1B10 and aldose reductase (AR): insight from molecular dynamics simulations and free energy calculations
por: Lin, Ping, et al.
Publicado: (2023)

Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide
por: Hong, Zhe, et al.
Publicado: (2021)

B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo
por: Wang, Pu, et al.
Publicado: (2020)

AKR1C1-3, notably AKR1C3, are distinct biomarkers for liver cancer diagnosis and prognosis: Database mining in malignancies
por: Zhao, Shou-Feng, et al.
Publicado: (2019)

Amplification of MUC1 in prostate cancer metastasis and CRPC development
por: Wong, Nicholas, et al.
Publicado: (2016)

Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy
por: Zeng, Chen-Ming, et al.
Publicado: (2017)

In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization
por: Ejaz, Syeda Abida, et al.
Publicado: (2022)

AKR1B10 in gastrointestinal diseases
por: Shen, Yi, et al.
Publicado: (2015)

Roles of AKR1C3 in malignancy
por: Xiao, Xin-Zhu, et al.
Publicado: (2021)

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line
por: Kljun, Jakob, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gbn9h2o8uid2bl7v0j506tp4qe