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microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis

BACKGROUND: The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B). METHODS: We first screened the differentially expressed miRNAs from the serum of 12 BC...

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Detalles Bibliográficos
Autores principales: Liu, Beibei, Sun, Wei, Gao, Wuyue, Li, Liqiang, Cao, Zhenxue, Yang, Xiaohuai, Liu, Jianmin, Guo, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579823/
https://www.ncbi.nlm.nih.gov/pubmed/33087088
http://dx.doi.org/10.1186/s12885-020-07523-8