Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

BACKGROUND: Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1(mut)) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to their newly acquired function: synthesis of 2-hydroxyglutara...

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Detalles Bibliográficos
Autores principales: Ruiz-Rodado, Victor, Lita, Adrian, Dowdy, Tyrone, Celiku, Orieta, Saldana, Alejandra Cavazos, Wang, Herui, Yang, Chun Zhang, Chari, Raj, Li, Aiguo, Zhang, Wei, Song, Hua, Zhang, Meili, Ahn, Susie, Davis, Dionne, Chen, Xiang, Zhuang, Zhengping, Herold-Mende, Christel, Walters, Kylie J., Gilbert, Mark R., Larion, Mioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579920/
https://www.ncbi.nlm.nih.gov/pubmed/33101674
http://dx.doi.org/10.1186/s40170-020-00229-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579920/
https://www.ncbi.nlm.nih.gov/pubmed/33101674
http://dx.doi.org/10.1186/s40170-020-00229-2

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