Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development

Thalamus is a critical information relay hub in the cortex; its malfunction causes multiple neurological and psychiatric disorders. However, there are no model systems to study the development and function of human thalamus. Here, we present a protocol to generate regionally specified human brain or...

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Detalles Bibliográficos
Autores principales: Xiang, Yangfei, Cakir, Bilal, Park, In-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580078/
https://www.ncbi.nlm.nih.gov/pubmed/33103124
http://dx.doi.org/10.1016/j.xpro.2019.100001
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author Xiang, Yangfei
Cakir, Bilal
Park, In-Hyun
author_facet Xiang, Yangfei
Cakir, Bilal
Park, In-Hyun
author_sort Xiang, Yangfei
collection PubMed
description Thalamus is a critical information relay hub in the cortex; its malfunction causes multiple neurological and psychiatric disorders. However, there are no model systems to study the development and function of human thalamus. Here, we present a protocol to generate regionally specified human brain organoids that recapitulate the development of the thalamus using human pluripotent stem cells (hPSCs). Thalamic organoids can be used to study human thalamus development, to model related diseases, and to discover potential therapeutics. For complete information on human thalamic organoids and their application, please refer to the paper by Xiang et al. (2019).
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spelling pubmed-75800782020-10-23 Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development Xiang, Yangfei Cakir, Bilal Park, In-Hyun STAR Protoc Protocol Thalamus is a critical information relay hub in the cortex; its malfunction causes multiple neurological and psychiatric disorders. However, there are no model systems to study the development and function of human thalamus. Here, we present a protocol to generate regionally specified human brain organoids that recapitulate the development of the thalamus using human pluripotent stem cells (hPSCs). Thalamic organoids can be used to study human thalamus development, to model related diseases, and to discover potential therapeutics. For complete information on human thalamic organoids and their application, please refer to the paper by Xiang et al. (2019). Elsevier 2020-06-04 /pmc/articles/PMC7580078/ /pubmed/33103124 http://dx.doi.org/10.1016/j.xpro.2019.100001 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Xiang, Yangfei
Cakir, Bilal
Park, In-Hyun
Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development
title Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development
title_full Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development
title_fullStr Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development
title_full_unstemmed Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development
title_short Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development
title_sort generation of regionally specified human brain organoids resembling thalamus development
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580078/
https://www.ncbi.nlm.nih.gov/pubmed/33103124
http://dx.doi.org/10.1016/j.xpro.2019.100001
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