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Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
Poly(β-L-malic acid) (PMLA) is a natural polyester produced by numerous microorganisms. Regarding its biosynthetic machinery, a nonribosomal peptide synthetase (NRPS) is proposed to direct polymerization of L-malic acid in vivo. Chemically versatile and biologically compatible, PMLA can be used as a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580597/ https://www.ncbi.nlm.nih.gov/pubmed/33268216 http://dx.doi.org/10.1016/j.tibs.2020.09.008 |