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Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine

Poly(β-L-malic acid) (PMLA) is a natural polyester produced by numerous microorganisms. Regarding its biosynthetic machinery, a nonribosomal peptide synthetase (NRPS) is proposed to direct polymerization of L-malic acid in vivo. Chemically versatile and biologically compatible, PMLA can be used as a...

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Detalles Bibliográficos
Autores principales: Zhang, Jianguo, Chen, Deyu, Liang, Guoxin, Xu, Wenrong, Tao, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580597/
https://www.ncbi.nlm.nih.gov/pubmed/33268216
http://dx.doi.org/10.1016/j.tibs.2020.09.008
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author Zhang, Jianguo
Chen, Deyu
Liang, Guoxin
Xu, Wenrong
Tao, Zhimin
author_facet Zhang, Jianguo
Chen, Deyu
Liang, Guoxin
Xu, Wenrong
Tao, Zhimin
author_sort Zhang, Jianguo
collection PubMed
description Poly(β-L-malic acid) (PMLA) is a natural polyester produced by numerous microorganisms. Regarding its biosynthetic machinery, a nonribosomal peptide synthetase (NRPS) is proposed to direct polymerization of L-malic acid in vivo. Chemically versatile and biologically compatible, PMLA can be used as an ideal carrier for several molecules, including nucleotides, proteins, chemotherapeutic drugs, and imaging agents, and can deliver multimodal theranostics through biological barriers such as the blood–brain barrier. We focus on PMLA biosynthesis in microorganisms, summarize the physicochemical and physiochemical characteristics of PMLA as a naturally derived polymeric delivery platform at nanoscale, and highlight the attachment of functional groups to enhance cancer detection and treatment.
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spelling pubmed-75805972020-10-23 Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine Zhang, Jianguo Chen, Deyu Liang, Guoxin Xu, Wenrong Tao, Zhimin Trends Biochem Sci Review Poly(β-L-malic acid) (PMLA) is a natural polyester produced by numerous microorganisms. Regarding its biosynthetic machinery, a nonribosomal peptide synthetase (NRPS) is proposed to direct polymerization of L-malic acid in vivo. Chemically versatile and biologically compatible, PMLA can be used as an ideal carrier for several molecules, including nucleotides, proteins, chemotherapeutic drugs, and imaging agents, and can deliver multimodal theranostics through biological barriers such as the blood–brain barrier. We focus on PMLA biosynthesis in microorganisms, summarize the physicochemical and physiochemical characteristics of PMLA as a naturally derived polymeric delivery platform at nanoscale, and highlight the attachment of functional groups to enhance cancer detection and treatment. Elsevier Ltd. 2021-03 2020-10-22 /pmc/articles/PMC7580597/ /pubmed/33268216 http://dx.doi.org/10.1016/j.tibs.2020.09.008 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Zhang, Jianguo
Chen, Deyu
Liang, Guoxin
Xu, Wenrong
Tao, Zhimin
Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
title Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
title_full Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
title_fullStr Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
title_full_unstemmed Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
title_short Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
title_sort biosynthetic polymalic acid as a delivery nanoplatform for translational cancer medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580597/
https://www.ncbi.nlm.nih.gov/pubmed/33268216
http://dx.doi.org/10.1016/j.tibs.2020.09.008
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