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Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort

Deflazacort (Emflaza) was approved in the United States in 2017 for the treatment of the Duchenne muscular dystrophy in patients aged 2 years and older. Several deflazacort metabolites were isolated and identified from rats, dogs, monkeys, and humans. Among them, 1ß,2ß‐epoxy‐3ß‐hydroxy‐21‐desacetyl...

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Detalles Bibliográficos
Autores principales: Kong, Ronald, Ma, Jiyuan, Beers, Brian, Kaushik, Diksha, Lin, E, Goodwin, Elizabeth, Colacino, Joseph, Bibbiani, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580709/
https://www.ncbi.nlm.nih.gov/pubmed/33090712
http://dx.doi.org/10.1002/prp2.677