Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl–deoxynojirimycin derivatives as potential α-glucosidase inhibitors

A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ∼ 44 were synthesised and evaluated for their in vitro α-glucosidase inhibitory activity to develop α-glucosidase inhibitors with high activity. All twenty compounds exhibited α-glucosidase inhibitory activity with IC(50) values ranging fro...

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Detalles Bibliográficos
Autores principales: Lin, Ping, Zeng, Jia-Cheng, Chen, Ji-Guang, Nie, Xu-Liang, Yuan, En, Wang, Xiao-Qiang, Peng, Da-Yong, Yin, Zhong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580737/
https://www.ncbi.nlm.nih.gov/pubmed/33003963
http://dx.doi.org/10.1080/14756366.2020.1826941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580737/
https://www.ncbi.nlm.nih.gov/pubmed/33003963
http://dx.doi.org/10.1080/14756366.2020.1826941

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