Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells

The dual phosphatases CDC25 are involved in cell cycle regulation and overexpressed in many tumours, including melanoma. CDC25 is a promising target for discovering anticancer drugs, and several studies focussed on characterisation of quinonoid CDC25 inhibitors, frequently causing undesired side tox...

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Detalles Bibliográficos
Autores principales: Aliotta, Federica, Nasso, Rosarita, Rullo, Rosario, Arcucci, Alessandro, Avagliano, Angelica, Simonetti, Martina, Sanità, Gennaro, Masullo, Mariorosario, Lavecchia, Antonio, Ruocco, Maria Rosaria, Vendittis, Emmanuele De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580834/
https://www.ncbi.nlm.nih.gov/pubmed/32990107
http://dx.doi.org/10.1080/14756366.2020.1819257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580834/
https://www.ncbi.nlm.nih.gov/pubmed/32990107
http://dx.doi.org/10.1080/14756366.2020.1819257

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