Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure

The voltage‐gated hERG (human‐Ether‐à‐go‐go Related Gene) K(+) channel plays a fundamental role in cardiac action potential repolarization. Loss‐of‐function mutations or pharmacological inhibition of hERG leads to long QT syndrome, whilst gain‐of‐function mutations lead to short QT syndrome. A recen...

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Detalles Bibliográficos
Autores principales: Zhang, Yihong, Dempsey, Christopher E., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580876/
https://www.ncbi.nlm.nih.gov/pubmed/33091232
http://dx.doi.org/10.14814/phy2.14568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580876/
https://www.ncbi.nlm.nih.gov/pubmed/33091232
http://dx.doi.org/10.14814/phy2.14568

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