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Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
The voltage‐gated hERG (human‐Ether‐à‐go‐go Related Gene) K(+) channel plays a fundamental role in cardiac action potential repolarization. Loss‐of‐function mutations or pharmacological inhibition of hERG leads to long QT syndrome, whilst gain‐of‐function mutations lead to short QT syndrome. A recen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580876/ https://www.ncbi.nlm.nih.gov/pubmed/33091232 http://dx.doi.org/10.14814/phy2.14568 |