Pan-sarcoma genomic analysis of KMT2A rearrangements reveals distinct subtypes defined by YAP1–KMT2A–YAP1 and VIM–KMT2A fusions

Sarcomas are driven by diverse pathogenic mechanisms, including gene rearrangements in a subset of cases. Rare soft tissue sarcomas containing KMT2A fusions have recently been reported, characterized by a predilection for young adults, sclerosing epithelioid fibrosarcoma-like morphology, and an ofte...

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Detalles Bibliográficos
Autores principales: Massoth, Lucas R., Hung, Yin P., Nardi, Valentina, Nielsen, G. Petur, Hasserjian, Robert P., Louissaint, Abner, Fisch, Adam S., Deshpande, Vikram, Zukerberg, Lawrence R., Lennerz, Jochen K., Selig, Martin, Glomski, Krzysztof, Patel, Parth J., Williams, Kevin Jon, Sokol, Ethan S., Alexander, Brian M., Vergilio, Jo-Anne, Ross, Jeffrey S., Pavlick, Dean C., Chebib, Ivan, Williams, Erik A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581494/
https://www.ncbi.nlm.nih.gov/pubmed/32461620
http://dx.doi.org/10.1038/s41379-020-0582-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581494/
https://www.ncbi.nlm.nih.gov/pubmed/32461620
http://dx.doi.org/10.1038/s41379-020-0582-4

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