An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency

Sumoylation is an essential posttranslational modification in eukaryotes that has emerged as an important pathway in oncogenic processes. Most human cancers display hyperactivated sumoylation and many cancer cells are remarkably sensitive to its inhibition, thus supporting application of chemical su...

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Detalles Bibliográficos
Autores principales: López, Ignacio, Chalatsi, Eleftheria, Ellenbroek, Saskia I. J., Andrieux, Alexandra, Roux, Pierre-François, Cerapio, Juan P., Jouvion, Grégory, van Rheenen, Jacco, Seeler, Jacob-S., Dejean, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581512/
https://www.ncbi.nlm.nih.gov/pubmed/32948837
http://dx.doi.org/10.1038/s41388-020-01457-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581512/
https://www.ncbi.nlm.nih.gov/pubmed/32948837
http://dx.doi.org/10.1038/s41388-020-01457-y

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