Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity

ABSTRACT: This study shows that melanoma-associated fibroblasts (MAFs) suppress cytotoxic T lymphocyte (CTL) activity and reveals a pivotal role played by arginase in this phenomenon. MAFs and normal dermal fibroblasts (DFs) were isolated from surgically resected melanomas and identified as Melan-A-...

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Detalles Bibliográficos
Autores principales: Érsek, Barbara, Silló, Pálma, Cakir, Ugur, Molnár, Viktor, Bencsik, András, Mayer, Balázs, Mezey, Eva, Kárpáti, Sarolta, Pós, Zoltán, Németh, Krisztián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581550/
https://www.ncbi.nlm.nih.gov/pubmed/32328671
http://dx.doi.org/10.1007/s00018-020-03517-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581550/
https://www.ncbi.nlm.nih.gov/pubmed/32328671
http://dx.doi.org/10.1007/s00018-020-03517-8

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