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Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
PURPOSE: To estimate the diffusion coefficients of an IgG antibody (150 kDa) and its antigen-binding fragment (Fab; 50 kDa) in the neural retina (D(ret)) and the combined retinal pigment epithelium-choroid (D(RPE-cho)) with a 3-dimensional (3D) ocular pharmacokinetic (PK) model of the rabbit eye. ME...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581578/ https://www.ncbi.nlm.nih.gov/pubmed/33094404 http://dx.doi.org/10.1007/s11095-020-02946-1 |