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Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor

PURPOSE: To estimate the diffusion coefficients of an IgG antibody (150 kDa) and its antigen-binding fragment (Fab; 50 kDa) in the neural retina (D(ret)) and the combined retinal pigment epithelium-choroid (D(RPE-cho)) with a 3-dimensional (3D) ocular pharmacokinetic (PK) model of the rabbit eye. ME...

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Detalles Bibliográficos
Autores principales: Lamminsalo, Marko, Karvinen, Timo, Subrizi, Astrid, Urtti, Arto, Ranta, Veli-Pekka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581578/
https://www.ncbi.nlm.nih.gov/pubmed/33094404
http://dx.doi.org/10.1007/s11095-020-02946-1