Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

BACKGROUND: In cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT. Yet, most cancers show only modest levels of TERT gene expression, even in the context of activating hotspot promoter mutations (C228T and C250T). The role of epi...

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Detalles Bibliográficos
Autores principales: Esopi, David, Graham, Mindy Kim, Brosnan-Cashman, Jacqueline A., Meyers, Jennifer, Vaghasia, Ajay, Gupta, Anuj, Kumar, Balasubramanian, Haffner, Michael C., Heaphy, Christopher M., De Marzo, Angelo M., Meeker, Alan K., Nelson, William G., Wheelan, Sarah J., Yegnasubramanian, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581602/
https://www.ncbi.nlm.nih.gov/pubmed/32468444
http://dx.doi.org/10.1007/s13402-020-00531-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581602/
https://www.ncbi.nlm.nih.gov/pubmed/32468444
http://dx.doi.org/10.1007/s13402-020-00531-7

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