Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain

Synaptotagmin interaction with anionic lipid (phosphatidylserine/phosphatidylinositol) containing membranes, both in the absence and presence of calcium ions (Ca(2+)), is critical to its central role in orchestrating neurotransmitter release. The molecular surfaces involved, namely the conserved pol...

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Detalles Bibliográficos
Autores principales: Gruget, Clémence, Bello, Oscar, Coleman, Jeff, Krishnakumar, Shyam S., Perez, Eric, Rothman, James E., Pincet, Frederic, Donaldson, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581758/
https://www.ncbi.nlm.nih.gov/pubmed/33093513
http://dx.doi.org/10.1038/s41598-020-74923-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581758/
https://www.ncbi.nlm.nih.gov/pubmed/33093513
http://dx.doi.org/10.1038/s41598-020-74923-y

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